A couple points off the top of my head on a very interesting discussion:
Cyber semi has a CD of .34~.36 with trailer - higher without.
Hub motors would be easy to implement up front, fairly easy on the front boogies (probably requiring beefed up Shur Trac) and would take some study on the rear boogie (definitely not designed to push the GMC).
Ditching the mirrors, front grill, going to flush headlights, stripping the roof and cleaning up the windshield/cockpit window gaskets would help a lot - big bonus if retracting wipers developed. Add aero wheel covers and fairly tight wheel skirts.
Lowering the suspension at speed and raking it towards the front (counter to best handling practice) in combination with front air-dam, side skirts and cleaned up underside make a big difference - effectively reduces frontal area some and helps with skin friction. Turbulators on the rear sides and top could tune the negative pressure behind the coach. A rudimentary venturi under the rear could suck wheel-well and under-body air into this zone. Anybody have a kid studying aerodynamics at a school with a big wind tunnel (rolling road as a tie breaker)?
If doing a deeper frame, make it aluminum (with Jim B's bracket extensions incorporated incorporated, and hockey puck spacers).
Now that the extra space is made, have to say I'm not a fan of multi-cylindrical cell batteries.
Re-floor with ¾" Coosa board, then glue on a ¼" cork layer and another ½" Coosa layer - sound and temp insulation.
For weight savings, gut and strip the interior - insulate with aerogel, wire for 48V DC/240 AC, formed aluminum (a la DJ Eberhart) cabinetry and faced honeycomb-cored sheet "furniture".