Last year, a route from Minnesota would take you interstate to Knoxville ish and then you could spend a few days in Pigeon Forge and Gatlinburg, Great Smoky Mountains on the way. Helene tore up the interstate you would use for a semi direct route, but that area has lots to do on the Tennessee side. Gatlinburg and Pigeon Forge are closer together than they sound, maybe 15 minutes by parkway. They are very touristy, but easy to get away from touristy also, but restaurants, zip lines, Dollywood, oddball museums in town, and of course hikes and nature in the parks.