Well...
There are no holes or gaps in the wheel well liners. I even plugged the holes for the seat base bolts.
There are no holes in the fenders for air.
The gap between the bumper and the body is filled with a PVC pipe used for vacuum reservoir.
The driver front cavity in front of the tire is where the engine air intake and filter box is located. There is shielding to try to keep hot air from going back between the wheel liner and radiator to go in the intake.
There is shielding on the passenger side of the motor also to protect the Fitech FCC.
There is a lot of dynamat and polyurethane sealer trying to direct airflow and reduce noise.
I have modified the radiator air intake significantly over factory. If it comes through the grill it has to either go through the radiator or through the dash vents. Everything else has been plugged with sheetmetal and EPDM rubber way better than the lousy factory setup.
If it goes under the bumper there are air guides there also as an attempt to keep the engine fan from sucking the same air through the radiator over and over when parked. It's a PITA to keep a Cadillac cool with a clutched fan.
At 40+mph there is little to no air that comes out of the wheelwells (testing in rain). Originally air came out of the wheelwells such that you were riding next to mist from the Big Sur while driving in the rain. There is a compression wave or whatever you want to call it about 2' in front of the front tires. It practically blasts the water off the ground. It reminds me of pulling my travel trailer (parachute) with my truck as far as air currents on the ground.
So yeah, lots of air changes from factory. However, other than switching to electric wipers nothing above the beltline is different other than the mirrors.
The cabin is quiet enough with the windows closed all you can hear is the gentle whine of the transmission at 65.
I was experimenting and if I open the window in front of the door about an inch the buffeting largely goes away.
I think the best part of these vehicles is being able to drive around with the windows open but to be honest I've never seen anyone drive around with their windows open.