Wow that is one very trusting friend to loan you their GMC.
Just be aware they are a 40 yo, 12000 lb FWD automobile. They stop like a 70's car used to stop at best, not great compared to a modern car. Leave plenty of room in front of you and keep your eyes well down the road.
Don't be in a rush, enjoy the trip as much or more than the destination.
Ask the owner about how often to check the oil and where it should be on the dipstick. It may burn a little and that's fine, just make sure to top it off.
Ask the owner about fuel octane and then put the next better grade in it. Last thing you want to do is destroy a friend's borrowed engine from pre-ignition / pinging just to save $0.20 a gallon on fuel. Keep an ear open for pinging especially climbing hills.
At fuel stops, walk around and check tire temperatures. Check for bad smells like brakes heating up.
Climbing hills, shift down into 2nd/Super before the kickdown does it for you. You want to be in 2nd/Super before you loose too much speed. You can do up to 60mph in Super continuously. If the gearing has been modified with a higher ratio Final Drive, then hopefully there's a tachometer, you can go continuously up to 3000 rpm without hurting anything. Maybe even a little higher but I personally don't like to race it for very long at anything over 3500rpm or so, that's just me. Drop it into 1st if you loose speed and get down to 35mph.
Descend hills using a lower gear to engine brake down the hill. If the engine can't hold back the coach in that gear then you need to hit the brakes briefly, but hard, and shift down into the next lower gear so the engine can act as the brake while going down the hill. If you don't do this and instead use the coach brakes to maintain speed while descending, you may end up with no brakes at the bottom of the hill. If there's a town down there, there's usually a stoplight and that's going to be a problem. 40mph in 1st is 3500rpm with the stock 3.07FD, and that's ok for a 12,000lb 40yo automobile based RV to go down a mountain side. Nobody's going to be mad at you for being a little careful coming down a mountain. And if they are, they'll get over it. Better than blowing through the town out of control with no brakes.
Enjoy your trip, but be careful, these are contagious! You'll probably end up owning one after this trip is done