Welcome Papillon! Consistently running the engine at high speeds (say, over 3250-3500 RPMs) will shorten its life; it wasn't really designed for that. It is also not good to "lug" it; if you're going up a steep hill and your speed drops below 40 mph in 3rd, manually downshifting into 2nd is a good idea.
With all that said, the speed at which you'll hit those RPMs varies depending on whether you have the factory final drive ratio (3.07), widely acknowledged to be too low numerically, or a replacement such as 3.55 (many agree this is ideal) or 3.70 (if towing heavy loads frequently in the mountains). I have a 3.50 ratio, achieved by changing the chain drive sprocket between the engine and transmission, and I typically cruise at 65 mph which puts the RPMs at about 2800 IIRC.
Finally, as you go faster your MPG will drop significantly, and it's not very good to begin with. All the weight and frontal area of the coach means that at 55 mph you'll be lucky to hit 10 MPG. At 75 mph you might get more like 7 MPG (guessing). And if you're always 'putting your foot in it' (accelerating heavily) such that the massive secondarys are opening up on the Quadrajet carburetor, don't even ask about MPG!
Here's an article with more detailed info:
http://gmcws.org/Tech/Final_Drive_Ratios.pdf